Caveolin-1−/− Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts
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چکیده
منابع مشابه
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Cancer-associated fibroblasts (CAF) have been suggested to originate from mesenchymal stromal cells (MSC), but their relationship with MSCs is not clear. Here, we have isolated from primary human neuroblastoma tumors a population of αFAP- and FSP-1-expressing CAFs that share phenotypic and functional characteristics with bone marrow-derived MSCs (BM-MSC). Analysis of human neuroblastoma tumors ...
متن کاملOverexpression of caveolin-1 in cancer-associated fibroblasts predicts good outcome in breast cancer.
BACKGROUND The aim of this study was to investigate the expression of caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) and to explore its correlation with clinicopathologic parameters and prognosis. MATERIALS AND METHODS Cav-1 expression was detected in the stroma of 143 patients with breast cancer, 10 patients with ductal carcinoma in situ (DCIS), and 10 normal breast tissue sample...
متن کاملArousal of cancer-associated stromal fibroblasts
Cancer-associated fibroblasts (CAF), comprised of activated fibroblasts or myofibroblasts, are found in stroma surrounding solid tumors; these myofibroblasts promote invasion and metastasis of cancer cells. Activation of stromal fibroblasts into myofibroblasts is induced by expression of cystoskeleton protein, palladin, at early stages in tumorigenesis and increases with neoplastic progression....
متن کاملStromal Fibroblasts in Cancer
Tumors are highly complex tissues composed of neoplastic cells and, in the case of carcinomas, stromal cell compartments containing a variety of mesenchymal cells, notably fibroblasts, myofibroblasts, endothelial cells, pericytes, and a variety of inflammatory cells associated with the immune system. Fibroblasts and myofibroblasts often represent the majority of the stromal cells within various...
متن کاملStromal fibroblasts influence human mammary epithelial cell morphogenesis.
T he inability to grow normal or premalignant human mammary epithelial cells as in vivo explants has thwarted research biologists for the past 30 years (1–4). Although human breast cancer cells can be passaged in vivo as a xenograft or in vitro as cell cultures, this capability does not extend to normal or premalignant human mammary cells, with a few rare exceptions (5). Previous studies have s...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2009
ISSN: 0002-9440
DOI: 10.2353/ajpath.2009.080658